For example, hypoplastic or aplastic enamel deficiencies are produced by amelogenin (Amel), ameloblastin (Ambn), and enamelin (Enam) mutations, recapitulating defects in patients (Gibson et al., 2001; Fukumoto et al., 2004; Masuya et al., 2005; Hu et al., 2008, 2014). Here, ENAM is linked to hyperinsulinemic hypoglycemia, familial, 4.