VEGFA and non-small cell lung carcinoma: Although the treatment with bevacizumab (Avastin, which neutralizes specifically the VEGF-A isoforms) and paclitaxel plus carboplatin (both chemotherapeutics) in the treatment of patients with non-small-cell lung cancer had significant survival benefits, febrile neutropenia and pulmonary hemorrhage were associated with the addition of anti-VEGF (Sandler et al., 2006).