Previous studies have demonstrated that the ApoB/ApoA-I ratio is an independent predictor of insulin resistance in US non-diabetic subjects32 and Chinese obese subjects.33 A possible explanation for the positive association between the ApoB/ApoA-I ratio and insulin resistance could be that both ApoB and insulin resistance are linked to an inflammatory state.34 However, detailed mechanisms interpreting this association need further exploration. The gene discussed is APOA1; the disease is Insulin resistance.