APOB and Insulin resistance: Previous studies have demonstrated that the ApoB/ApoA-I ratio is an independent predictor of insulin resistance in US non-diabetic subjects32 and Chinese obese subjects.33 A possible explanation for the positive association between the ApoB/ApoA-I ratio and insulin resistance could be that both ApoB and insulin resistance are linked to an inflammatory state.34 However, detailed mechanisms interpreting this association need further exploration.