CDC7 and acute myeloid leukemia: Moreover additional genes were downregulated by the treatment with GANT61 (p < 0.05), as for example, genes involved in cell cycle control, such as CDC25A, CDC7, CDCA2, and CCNA2. The expression of these genes is required for progression through cell cycle, and their expression is aberrant in AML, as well as in other malignancies [9, 10].