To determine whether Sema7A elicits integrin-dependent signaling responses in CD14+ monocytes from patients with RA, we measured the level of FAK phosphorylation by performing immunoblot analysis in CD14+ monocytes and THP-1 cells stimulated with Sema7A or DSema7A for 1 h. The gene discussed is SEMA7A; the disease is rheumatoid arthritis.