In this paper, our results are consistent with previous studies; we found that LPS-induced cognitive impairment was associated with decreased Bcl-2 expression and an elevated Bax/Bcl-2 ratio and that APAP protects against apoptosis, thereby assuaging cognitive impairment, by increasing the expression of anti-apoptotic Bcl-2 proteins and decreasing the hippocampal neuron apoptosis. Here, BAX is linked to Cognitive impairment.