For instance, Parkinson’s disease (PD) patients are disrupted for the cortisol and melatonin rhythms (Breen et al., 2014; Videnovic et al., 2014), and displayed Bmal1 reduce in blood samples from PD patients (Cai et al., 2010), these all point toward the deteriorated situations in circadian control. This evidence concerns the gene BMAL1 and Parkinson disease.