A PD transgenic model via Thy-1 promoter mediated α-synuclein over-expression exhibited several circadian phenotypes in aging: a clear reduced wheel-running activity with altered period, altered temporal distribution of sleep, and decayed spontaneous neural activity in the SCN, suggested circadian rhythm is severely disrupted in the PD model (Kudo et al., 2011). Here, THY1 is linked to Parkinson disease.