TPO and mood disorder: In the DBO cohort, TPO-Abs positivity was independent from the vulnerability to develop a mood disorder; of the 11 TPO-Abs positive subjects, 9.1% were bipolar, 54.5% unipolar, and 36.3% had no disorder, whereas of the 92 TPO-Abs negative subjects, 14.1% were bipolar, 39.1% unipolar, and 26,1% had no disorder and 20.7% other disorders (p = .33).