Other mutated genes including U2AF1, SRSF2, DNMT3A, IDH1/2, SETBP1 and CBL have been associated with poor survival and progression to AML (Bejar et al. 2011; Graubert et al. 2011, 2012; Haferlach et al. 2014; Kosmider et al. 2010; Makishima et al. 2013; Pardanani et al. 2010; Thol et al. 2012; Walter et al. 2011). Here, CBL is linked to acute myeloid leukemia.