In this study, we selected seven potential functional SNPs (rs1050390, rs1050461, rs2285747, rs2472614, rs3786054, rs4790264, and rs8072363) in the HABP1 gene from the dbSNP and HapMap databases using a combined analysis of functional significance and Tag SNP strategies, and performed genotyping analyses in 505 breast cancer patients and 505 healthy controls to investigate the associations of HABP1 gene polymorphisms with breast cancer susceptibility, the survival, the clinicopathological features and the HABP1 protein expression in a population from northeast China, Heilongjiang Province. The gene discussed is C1QBP; the disease is breast cancer.