HOTAIR can increase the expression of E-cadherin and decrease the expression of vimentin and matrix metallopeptidase 9 to function as a pleiotropic modulator participating in epithelial-mesenchymal transition (EMT), which is involved in CRC invasion, lymph node and organ metastasis, differentiation, vascular invasion and tumor staging [20]. The gene discussed is CDH1; the disease is neoplasm.