Cancer susceptibility candidate 2 (CASC2) can act as an “miRNA sponges” and ceRNA by sponging miR-18a to upregulate protein inhibitor of activated signal transducer and activator of transcription 3 (PIAS3) and then consequentially inhibit of CRC cell proliferation and tumor growth by extending the G0/G1-S phase transition [8]. The gene discussed is CASC2; the disease is neoplasm.