In order to ascertain whether FAK, Src, ERK1/2, PPARγ, C21orf34 (miR-125b host gene), Stat3 and E-cadherin were differentially expressed in human melanoma tissues, we firstly analyzed their mRNA levels in melanoma cancer using Oncomine Cancer Microarray database (www.oncomine.org). This evidence concerns the gene MAPK3 and melanoma.