In the latest meta-analysis of GWAS studies in PD (Nalls et al., 2014), two single nucleotide polymorphisms (SNPs) in the intron 1 of CPLX1 directly next to the GAK gene reached genome-wide significance (rs76444973 and rs34006598), but it is difficult to predict how these variants would influence the function of CPLX1 protein. Here, CPLX1 is linked to Parkinson disease.