Several other components of the SNARE complex that mediate membrane fusion and vesicle exocytosis, namely SNAP25, syntaxin 1 and synaptobrevin 2 (VAMP2), are contained in Lewy bodies and are depleted from surrounding neural tissue in PD (Garcia-Reitbock et al., 2010; Mukaetova-Ladinska et al., 2013). This evidence concerns the gene SNAP25 and Parkinson disease.