CPLX1 and Parkinson disease: CPLX1 protein accumulated in neuroblastoma cells (proteins extracted with RIPA buffer) in our experiments and is known to accumulate together with SNCA in midbrain tissue (proteins extracted with 7 M urea, 2 M thiourea and 4% CHAPS), whereas it is decreased in the prefrontal cortex of individuals with sporadic PD (proteins extracted with 8 M urea; Basso et al., 2004; Dumitriu et al., 2016).