Enhanced apoptotic vulnerability of human PARK1 lymphocytes and SNCA-transfected myeloma and leukemia cell lines to oxidative stress (Kim et al., 2004; Battisti et al., 2008), impaired innate immune functions of mouse leukocytes with SNCA overexpression (Gardai et al., 2013) and dose-dependent inhibition of α-granule release in human platelets exposed to exogenous SNCA (Park et al., 2002) provide evidence that biomarkers of elevated SNCA abundance and of the risk of synucleinopathy can be identified in peripheral tissues. Here, SNCA is linked to leukemia.