These approaches recently permitted us to identify three gene expression changes in dependence of SNCA function in brain tissue, concerning the chemotaxis factor Lect1 (Cnmd) in one digenic and two monogenic PD mouse models (Gispert et al., 2015a) and the midbrain-selective transcription factor Foxp1 and the SNARE complex component Cplx1 in a synucleinopathy model and SNCA-deficient mouse mutants (Gispert et al., 2015b). This evidence concerns the gene SNCA and synucleinopathy.