PIK3CA and hepatoblastoma: We also identified thioridazine, an antipsychotic agent which was recently shown to inhibit the PI3K-AKT-mTOR pathway in endometrial or cervical cancer cells [48, 49]; perhexiline, a Ca2+ channel blocker that also targets PI3K-AKT-mTOR dependent autophagy [50]; and betulin, a plant-derived inhibitor of sterol regulatory element-binding proteins that has also been shown to inhibit PI3K-AKT-mediated growth of hepatoblastoma cells [51, 52].