Importantly, the knowledge that RGS2 expression is induced in the human airways following ICS inhalation and the fact that in primary airway epithelial and smooth muscle cells glucocorticoids and LABAs synergistically induce RGS2 expression is also consistent with a therapeutically beneficial role of RGS2 expression in asthma [9, 13, 17]. This evidence concerns the gene RGS2 and asthma.