In principle, glycemic control should avoid blood glucose exceeding 180 mg/dL, but also pay attention to the development of hypoglycemia, and wide fluctuations in glucose levels which demonstrated an increased mortality, i.e., when a standardized approach for blood glucose management in ICU patients with severe sepsis is attempted, insulin administration can be considered when two consecutive blood glucose tests are exceed 180 mg/dL, also a less strict upper blood glucose target of ≤180 mg/dL rather than ≤ 110 mg/dL should be chosen. This evidence concerns the gene INS and Hypoglycemia.