The Barcelona Clinic Liver Cancer (BCLC) staging system was modified by replacing CTP class with IGF-CTP class, and the C-index of the modified BCLC stage (0.732, 95% CI = 0.586–0.787) was also higher than that of original BCLC stage (0.698, 95% CI = 0.554–0.842). The gene discussed is IGF1; the disease is liver cancer.