MAPT and nervous system disorder: These animal results are in agreement with the increased neurological disorder with markedly elevated levels of phospho-tau and abnormal NFTs in HIV-infected people with HAND compared to healthy normal individuals or HIV-1 infected people without HAND [58], similar to those of other reports [20, 33, 34, 61], although other reports suggested that phospho-tau-Thr181 does not appear to be important in neurodegeneration in HIV-infected people [62, 63].