Based on these facts and reasons, it is highly desirable to study the status of many other phosphorylation sites of tau, instead of only determining the levels of total tau and/or p-tau-Thr181 in making final conclusion, since tauopathy seems more closely correlated with the dementia status and a better predictor of cognitive function than amyloid deposits [65]. The gene discussed is MAPT; the disease is tauopathy.