In our previous study, STAT4, one of the most associated gene with RA susceptibility, related with a higher susceptibility to develop RA and with ACPA positivity, while SNPs in PSORS1C1 and PTPN2 genes were differently associated with joint damage in RA, even if we did not observe an association with RA susceptibility [21]. This evidence concerns the gene PTPN2 and rheumatoid arthritis.