Regarding CD4+ T cell differentiation, we observed an increased frequency of central memory CD45RA- CD62L+ CD4+ T cells in NT1 patients compared to HD (17.7 ± 1.7% in HD vs 26.9 ± 2.4% in NT1, p = 0.001) whereas naïve CD45RA+ CD62L+ CD4+ T cells and CD45RA- CD62L- CD4+ effector memory frequencies were not significantly different (Fig 1A). Here, CD4 is linked to Huntington disease.