In response to acute exogenous leptin, the degree to which pSTAT3 levels increase towards to those of never-obese controls ranges from no recovery (ARH, DMH and STN for either intervention), to partial recovery (NTS and SUM for CR), to increases beyond those observed in LF mice (Amg and DR for CR group; CO, MM, NTS, and SUM for HF-LF group; LC and PVT for either weight loss group). This evidence concerns the gene LEP and hydrops fetalis.