LEP and spindle cell hemangioma: In these HF-LF mice, reduced exogenous leptin sensing (compared to LF) was observed in twelve brain regions in a manner that was either independent of elevated basal STAT3 phosphorylation (DR, Hbn, PSV, PVH, SCH, and VMH) or driven, at least in part, by increased pSTAT3 levels in saline-treated controls (ARH, DMH, PB, PM, SNc, and STN) (Figs 4 and 5, Tables 1 and 2, and S3 Table).