Increased constitutive STAT3 phosphorylation (in the absence of exogenous leptin administration) was also observed in multiple brain regions in weight-perturbed mice: PSV and VMH for HF; LC for CR; BST, PB, PM, PVH and SUM for HF-LF; ARH, DMH and STN for both CR and HF-LF (S2 and S3 Figs). The gene discussed is LEP; the disease is hydrops fetalis.