Leptin-induced pSTAT3 levels were decreased >40% in the ACB, Amg, ARH, DMH, NTS, PAG, PVH, PVT, SFO, SNc, STN, SUM, and VMH; a >90% decrease was observed in the CO, LC, MM, PB, PSV, and SCH. The gene discussed is LEP; the disease is spindle cell hemangioma.