Further analysis combined with clinical data showed that serum ADAMTSL4 levels were much higher in patients with Lymph node metastasis of N0/N1 than those with N2/N3, and also much higher in early NPC patients than advanced NPC patients, which further confirmed the negative correlation of serum ADAMTSL4 levels with lymph node metastasis and clinical stage of NPC. This evidence concerns the gene ADAMTSL4 and metastatic malignant neoplasm in the lymph nodes.