Intriguingly, more and more evidence supports the novel notion of HIPK2 being a key regulator of the NF-kB signaling pathway, which often promotes abnormal expression of tumor-associated genes that inhibits cell apoptosis and increases angiogenesis and tumor metastasis, thereby directly promoting the incidence and development of malignant tumors [48]. The gene discussed is NFKB1; the disease is neoplasm.