ANRIL overlaps at its 5′ end with CDKN2B, and may have a role in the regulation of the expression of adjacent protein coding genes, including MTAP, CDKN2A and CDKN2B, suggesting that SNPs in ANRIL are more likely to contribute to the susceptibility of CAD. The gene discussed is CDKN2B-AS1; the disease is coronary artery disorder.