TP53 and cancer: This localization is in line with the complex role played by WT1 in diverse cellular activities and the modulation of many genes and cofactors including i) interaction with actin as a specific adaptor protein in carrying on the cytoskeletal changes activated in cancer cells in both nucleus and cytoplasm [48], ii) relationship with p53 and STAT3 in carrying on influence of target genes triggering cell proliferation [49, 50], iii) activity in nuclear-cytoplasmic shuttling under appropriate conditions consistent with its high expression level in the perinuclear zone of MG-63 cells [51].