SFRP1 and familial pancreatic carcinoma: Consistent with our result, the findings from Zhou's study also demonstrated that high level of miR-744 displayed the capacity to aberrantly activate Wnt/β-catenin signaling by directly suppressing the production of three negative regulators of Wnt/β-catenin pathway (SFRP1, GSK3β and TLE3), resulted in promoting the carcinogenesis of pancreatic cancer [23].