EGFR and infection: Similarly, the use of EGFR-TKIs alone had a tendency to increase the risk of all-grade infections when compared to placebo (Peto OR 2.24, 95%CI: 0.27-18.53, p = 0.45) or chemotherapy alone (Peto OR 1.93, 95%CI: 0.88-4.26, p = 0.10).