In addition to reducing HA accumulation (Figure 7A), 4-MU (1 mM) or HAS3 neutralization (10 μg/mL) signficantly attenuated oral cancer cell migration and invasion, and decreased HAS3-mediated increase of relative MCP1 expression in oral cancer cells (Figure 7B-7C). The gene discussed is HAS3; the disease is lip and oral cavity carcinoma.