CCNE1 and inflammatory breast carcinoma: To establish the clinical relevance of cyclin E as a therapeutic target in IBC, we examined the expression and localization of cyclin E in IBC samples from patients who received treatment or had consults at MD Anderson Cancer Center, using our previously established immunohistochemical method that incorporates both nuclear and cytoplasmic staining, and we compared these results to those for a large cohort of 2510 patients with non-inflammatory breast cancer [15, 16].