In the current study, we found that M + D significantly inhibited the cell apoptosis through suppressing the expression of Bax proteins, and increasing the expression of Bcl-2 proteins so as to maintain the ratio of Bcl-2 to Bax balance, which further demonstrated that the combination of Mor and Dio produced the greatest protective effect on DCM via the Bax signaling pathway. The gene discussed is BAX; the disease is familial dilated cardiomyopathy.