Deficiency in ITCH or CYLD causes sustained activation of TAK1 and increased cytokine production in bone marrow-derived macrophages, and tumorigenesis and metastasis of transplanted Lewis lung carcinoma, suggesting that sustained activation of TAK1 leads to the progression of non-small-cell lung cancer (NSCLC) [78]. Here, MAP3K7 is linked to Carcinoma, Lewis Lung.