The REACH-2 trial investigates the effects of ramucirumab as second line treatment after sorafenib on patients with advanced HCC and elevated baseline AFP ≥ 400 ng/mL, after observing favorable effects of ramucirumab only on patients of this subgroup in the REACH trial, while the overall cohort of the study was negative [86,101]. Here, AFP is linked to hepatocellular carcinoma.