ST6GAL1 and colon adenocarcinoma: Consistent with this, ST6Gal I expression was required for β1-integrin sialylation and enhanced adhesion to and migration along collagen substrates in colon adenocarcinoma cells [195], and ST6Gal-I-dependent α2-6 sialylation of integrins in mouse hepatocarcinoma H22 cells increased α5β1 integrin-dependent cell adhesion to fibronectin [196].