GLO1 and diabetes mellitus: Indeed, reduced activity of Glo1, inducible by treatment with the chemical Glo1 inhibitor SpBrBzGSHCp2 or by silencing Glo1 expression [105,106], mimics the physiological condition of endogenous accumulation of MGO as a consequence of MGO/Glo1 imbalance, occurring in both diabetes and ageing [107].