In a passive asthma model, where OVA-specific Th2 cells transfected with Ca(v)1 ASO were adoptively transferred into naive mice followed by challenged with OVA, it was shown that Th2 cells transfected with Ca(v)1 ASO had impaired Ca(2+) signaling and Th2 cytokine production and had also lost their ability to induce airway inflammation in vivo [61]. This evidence concerns the gene CAV1 and asthma.