The ectopic expression of miR-145 downregulated c-Myc expression at the translation level and decreased the PKM2/PKM1 ratio in both bladder cancer T24 and 253JB-V cells (Figure 4B), thus suggesting that miR-145 controlled the cancer specific energy metabolism through the c-Myc/PTBP1/PKMs axis. The gene discussed is PKM; the disease is cancer.