Using a hypertensive animal model in vivo and a cyclic stretch application system in vitro, we investigated the roles of secreted miRs in intercellular communication between ECs and VSMCs in response to mechanical cyclic stretch and also determined the effects of GRK6 modulated by secreted miR-27a on the abnormal proliferation of ECs in hypertension. The gene discussed is GRK6; the disease is Hypertension.