Numerous clinical variables were identified as independent predictors of VLRAF: non-paroxysmal AF, aging, LV systolic and diastolic dysfunction, high preoperative C-reactive protein level, LA enlargement, higher CHADS2 score, the presence of non-PV triggers, obesity, hypertension, hyperlipidaemia and ERAF4, 5, 7, 17, 18, 25, 26, 27. This evidence concerns the gene CRP and obesity disorder.