In order to investigate the cause-effect relationship between TGF-beta hyperactivity and the development of myopathy in ERO1-injected SEPN1 KO mice, we systemically antagonised TGF-beta in vivo by intraperitoneally injecting 1 mg/kg of neutralising antibody from the age of five weeks, as has been done when treating other myopathic states19. The gene discussed is SELENON; the disease is myopathy.