OTX2 and complication: It is distinctly seen that some of the identified gene loci are also associated with genetic disorders that are prevalent in the Arabian Peninsula - such gene loci include: C1orf106 associated with autoimmune disorders; [OTX2-AS1,RPL3P3] with hypogonadism; [THSD4,NR2E3] in several eye-related disorders including enhanced S-cone syndrome; [IGF1,PAH] in diabetic retinopathy, growth retardation with deafness and mental retardation (due to IGF1 deficiency); [TRA,TRD] in immune-related disorders; LAMA4 in diabetic nephropathy; and KSR1 in diabetic vascular complications.