Involvement of some of the identified gene loci (namely Chr15:40531386/ZNF106, Chr12:101494770/[IGF1,PAH], rs883431/SLC28A3, rs925530/TMEM120B, and rs17716285/KSR1) in processes relating to metabolic traits have been previously demonstrated in mice or cell lines18, 28, 49, 50, 51 (see Table 5). Here, KSR1 is linked to pulmonary arterial hypertension.