INS and obesity due to melanocortin 4 receptor deficiency: The identified gene loci was seen to map to the canonical pathways of Ceramide signaling, Pregnenolone biosynthesis, ERK/MAPK signaling, Histidine Degradation, and LPS/IL-1 Mediated inhibition of RXR function; all these five pathways relate to pathogenesis of obesity, insulin resistance and signaling.