Involvement of some of the identified gene loci (namely Chr15:40531386/ZNF106, Chr12:101494770/[IGF1,PAH], rs883431/SLC28A3, rs925530/TMEM120B, and rs17716285/KSR1) in processes relating to metabolic traits have been previously demonstrated in mice or cell lines18, 28, 49, 50, 51 (see Table 5). This evidence concerns the gene ZNF106 and pulmonary arterial hypertension.