PLG and obesity due to melanocortin 4 receptor deficiency: For example: PLG, PLAT, PLAUR, norepinephrine, TNF, MMP9, FYN and SHARPIN are involved in the etiology of dyslipidemia, hypertension, and cardiovascular disease (CVD); APC and CCND1 are associated with obesity; SUMO2, SMAD2, INS1, WNT1, TGFB1, TRAF2, and CCAR2 are associated with diabetes; whereas CCND1, TNF, MMP9, and norepinephrine are associated with comorbid conditions of metabolic disorders.