Established susceptibility gene loci for traits relating to obesity and diabetes in European population have been tested for replication in other ethnic population groups; such exemplary loci that are known to replicate well in other ethnic population groups (such as Indians and Russians) include PPARg, KCNJ11, TCF7L2, SLC30A, ABCC8, HHEX, CDKN2A, IGF2BP2, CDKAL1, and FTO32, 33, 34. The gene discussed is CDKAL1; the disease is obesity due to melanocortin 4 receptor deficiency.