This cross-talk of p53 and Notch-Wnt pathways by means of stress imparted in the pathways can have different regulatory mechanisms, namely, p53 activated apoptosis in T-cell Lymphocytes is suppressed by Notch signaling34, Notch activates p53 in neuronal progenitor cell35, 36, alteration of p53 and Notch in cancer cell37 etc. However, these complicated cross-talks are still far from proper understanding at fundamental level. The gene discussed is TP53; the disease is cancer.