Monogenic obesity also results from mutations in some other genes involved in eating behavior and energy balance regulation: (1) brain-derived neurotrophic factor (BDNF) [13]; (2) its receptor, tyrosine receptor kinase B (NTRK2) [14]; (3) SH2B adaptor protein 1 (SH2B1), involved in the regulation of leptin signaling [15, 16]; (4) KSR2, which encodes a scaffolding protein kinase suppressor of Ras 2, participating in signaling pathways relevant to glucose homoeostasis and food intake control [17]; (5) TUB, encoding Tubby bipartite transcription factor [18]. Here, SH2B1 is linked to inherited obesity.