This figure shows that the rs200487063-caused significant downregulation of reporter gene LUC is approximately twofold in both cell lines: HCT116 (human colon adenocarcinoma exemplifying basal expression of the human LEP gene) and MCF-7 (carcinoma of the human mammary gland epithelium exemplifying tissue-specific expression of this gene), at α < 0.05 according to Student’s t-test (asterisks in Fig. 2). This evidence concerns the gene LEP and colon adenocarcinoma.