NOS3 and hypertensive disorder: This group contained several genes associated with hypertension and some of them (Cyp1a1, cytochrome P450, family 1, subfamily a, polypeptide 1; Cyp4f1, cytochrome P450, family 4, subfamily f, polypeptide 1; Nos3, nitric oxide synthase 3, endothelial cell; Nox4, NADPH oxidase 4, Sod3, superoxide dismutase 3, extracellular) are known as involved in modulation of vascular tone and renal tubular function.