The list of the top 40 genes with the highest differences in their expression in renal medulla of ISIAH and WAG rats included two genes (Acsm3, acyl-CoA synthetase medium-chain family member 3; and Ephx2, epoxide hydrolase 2, cytoplasmic), which were annotated in Rat Genome Database (RGD) as genes related to hypertension (Table 1). The gene discussed is EPHX2; the disease is hypertensive disorder.