Our study revealed tumor-associated changes in alternative splicing patterns of seven genes involved in energy metabolism, including OGDH, COL6A3, ICAM1, PHPT1, PPP2R5D, SLC29A1, and TRIB3. OGDH gene encodes a subunit of the multi-enzyme 2-oxoglutarate dehydrogenase complex (OGDHC) that is the first and rate-limiting component of one [51]. This evidence concerns the gene PHPT1 and neoplasm.