SMARCA4 and cancer: The data cancer related-genes shows that Brg1 and/or Brm loss functions to down-regulate genes that are involved in cell adhesion, differentiation, apoptosis, drug metabolism, metabolism, and immunity, whereas Brg1/Brm loss also causes the up-regulation of genes involved in angiogenesis, anti-apoptosis, cancer progression, metastasis and proliferation (Tables 1 and 2).