Conversely, IgG4 can block the IgE-mediated immune response, contributing to the persistence of asymptomatic strongyloidiasis [63]. Strongyloides infection can also stimulate regulatory T cells (T reg), an escape mechanism of the parasite, which suppresses the protective immune response, such as the eosinophil-dependent activation by IL-5 [64]. The gene discussed is IGHE; the disease is strongyloidiasis.