Previously, others have shown that Cox2 plays a critical role in whole-body energy homeostasis and adipose tissue metabolism; for example, selective inhibition of Cox2 was shown to attenuate weight loss and energy expenditure in cancer patients and tumor-bearing mice [41, 42], and genetically manipulated mice that express only one wild-type allele of Cox2 were shown to exhibit fat accumulation [43]. The gene discussed is PTGS2; the disease is cancer.