Platelets can transfer MHC class I antigens to tumor cells, protecting them from T-cell mediated immunity without inducing NK cell cytotoxicity and IFN-γ production (Placke et al., 2011, 2012), and direct platelet inhibition of tumor cell lysis by NK cells can also occur in an MHC-independent manner (Nieswandt et al., 1999). The gene discussed is HLA-C; the disease is neoplasm.