By taking the advantages of O2‐generation from the reaction between catalase and H2O2, Guo and co‐workers prepared an interesting carrier system that can generate O2 and deliver anticancer drugs in response to high H2O2 levels in the tumor microenvironment.59 Biocompatible PLGA nanoparticles were chosen as the drug carrier, in which catalase and platinum‐based drug as O2‐generating agent and anticancer agent respectively, were loaded into aqueous core by double emulsion method. This evidence concerns the gene CAT and neoplasm.